Pub. Date : 1999 Mar 1
PMID : 9952321
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | At 40 microM PteGlu, the intensity of the combined action in all cell lines was increased However, the most intense Loewe synergy was seen with HCT-8, HCT-8/DF2, H460, FaDu, A253, and Hep-2/500 cells, whereas the HCT-8/50 subculture showed less of the phenomenon, and PteGlu enhancement was the least with HCT-8/DW2, a subline deficient in folylpolyglutamate synthetase (FPGS). | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
2 | At 40 microM PteGlu, the intensity of the combined action in all cell lines was increased However, the most intense Loewe synergy was seen with HCT-8, HCT-8/DF2, H460, FaDu, A253, and Hep-2/500 cells, whereas the HCT-8/50 subculture showed less of the phenomenon, and PteGlu enhancement was the least with HCT-8/DW2, a subline deficient in folylpolyglutamate synthetase (FPGS). | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
3 | Impaired FPGS activity and low-folate adaptation prior to treatment significantly lessen the degree of PteGlu enhancement. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |