Title : Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: biochemical characterization and biological consequences in endothelial cell cultures.

Pub. Date : 1999 Feb

PMID : 9950679






3 Functional Relationships(s)
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1 Also, gangliosides protect native FGF-2 from trypsin digestion at micromolar concentrations, the order of relative potency being GT1b > GD1b > GM1 = GM2 = sulfatide > GM3 = galactosyl-ceramide, whereas asialo-GM1, neuraminic acid, and N-acetylneuramin-lactose were ineffective. G(M1) Ganglioside fibroblast growth factor 2 Homo sapiens
2 Accordingly, GT1b,GD1b, GM1, and GM2, but not GM3 and asialo-GM1, prevent the binding of 125I-FGF-2 to a soluble, recombinant form of extracellular FGFR-1. G(M1) Ganglioside fibroblast growth factor 2 Homo sapiens
3 Conversely, the soluble receptor and free heparin inhibit the interaction of fluorochrome-labeled GM1 to immobilized FGF-2. G(M1) Ganglioside fibroblast growth factor 2 Homo sapiens