Title : Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.

Pub. Date : 1999 Feb 15

PMID : 9933028






1 Functional Relationships(s)
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Protein Name
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1 Both drugs are phosphorylated by deoxycytidine kinase (dCK); the triphosphates, dFdCTP and ara-CTP, respectively, are incorporated into DNA. triphosphoric acid sticky Drosophila melanogaster