Title : Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes.

Pub. Date : 1999 Jan 29

PMID : 9931427






1 Functional Relationships(s)
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1 Troleandomycin, a specific inhibitor of CYP3A4 and 3A5, inhibited the 25-hydroxylase activity of pooled human liver microsomes by more than 90% at 50 microM. Troleandomycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens