Title : Activation of heterocyclic amines by combinations of prostaglandin H synthase-1 and -2 with N-acetyltransferase 1 and 2.

Pub. Date : 1998 Nov 13

PMID : 9929169






1 Functional Relationships(s)
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1 We found that metabolic activation of one of these heterocyclic amines, the quinoline derivative 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), can be catalyzed by prostaglandin H synthase (PHS) as well as by CYP1A2. Amines cytochrome P450 family 1 subfamily A member 2 Homo sapiens