Pub. Date : 1998 Dec 11
PMID : 9928058
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of VIP and PACAP on vascular and luminal release of serotonin from isolated perfused rat duodenum. | Serotonin | vasoactive intestinal peptide | Rattus norvegicus |
| 2 | VIP, PACAP 38 and 27 reduced the release of 5HT into the lumen but did not affect the vascular release of 5HT. | Serotonin | vasoactive intestinal peptide | Rattus norvegicus |
| 3 | These effects were not affected by the presence of atropine, hexamethonium, or TTX, suggesting that VIP, PACAP 38 and 27 exert a direct inhibitory effect on the luminal release of 5HT from the EC cells. | Serotonin | vasoactive intestinal peptide | Rattus norvegicus |
| 4 | Nitric oxide synthase inhibitor, NG-nitro-L-arginine, antagonized the inhibitory effects of VIP, PACAP 38 and 27, suggesting that nitric oxide seems to be essential to exert the inhibitory action of VIP and PACAPs on the release of 5HT into the intestinal lumen from the EC cells. | Serotonin | vasoactive intestinal peptide | Rattus norvegicus |
| 5 | Nitric oxide synthase inhibitor, NG-nitro-L-arginine, antagonized the inhibitory effects of VIP, PACAP 38 and 27, suggesting that nitric oxide seems to be essential to exert the inhibitory action of VIP and PACAPs on the release of 5HT into the intestinal lumen from the EC cells. | Serotonin | vasoactive intestinal peptide | Rattus norvegicus |