Title : Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway.

Pub. Date : 1999 Jan 15

PMID : 9927052






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Overexpression of a dominant-negative mutant mitogen-activated protein kinase kinase kinase 1 (MEKK1-DN) or treatment with JNK-specific antisense oligonucleotide or Vit C all prevented beta-Lap-induced JNK activation and the subsequent apoptosis. Oligonucleotides mitogen-activated protein kinase 8 Homo sapiens
2 Overexpression of a dominant-negative mutant mitogen-activated protein kinase kinase kinase 1 (MEKK1-DN) or treatment with JNK-specific antisense oligonucleotide or Vit C all prevented beta-Lap-induced JNK activation and the subsequent apoptosis. Oligonucleotides mitogen-activated protein kinase 8 Homo sapiens