Title : Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro.

Pub. Date : 1998 Nov-Dec

PMID : 9923577






1 Functional Relationships(s)
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1 OBJECTIVE: The potent CYP1A2 inhibitor fluvoxamine has recently been shown also to be an effective inhibitor of the CYP2C19-mediated metabolism of the antimalarial drug proguanil in vivo. Fluvoxamine cytochrome P450 family 1 subfamily A member 2 Homo sapiens