Title : Selectively induced high MRP gene expression in multidrug-resistant human HL60 leukemia cells.

Pub. Date : 1999 Jan

PMID : 9923448






2 Functional Relationships(s)
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1 Southern blot analysis of the gene organization in the HL60/DOX cells revealed the amplification of MRP gene. Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens
2 These results indicate that alteration of the drug accumulation from enhanced efflux appears to be a major mechanism(s) of MDR phenotype and attributable to high levels of MRP expression in the HL60/DOX cells. Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens