Title : 6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species.

Pub. Date : 1998 Dec 8

PMID : 9920387






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The data suggest that the activity of 6PGDH is subjected to a two-way regulation: NADPH, which regulates the pentose phosphate pathway, inhibits the enzyme, while 6-phosphogluconate, levels of which rise when NADPH inhibition is removed, acts as an activator ensuring that 6-phosphogluconate is rapidly removed. NADP 6-phosphogluconate dehydrogenase, decarboxylating Ovis aries
2 The data suggest that the activity of 6PGDH is subjected to a two-way regulation: NADPH, which regulates the pentose phosphate pathway, inhibits the enzyme, while 6-phosphogluconate, levels of which rise when NADPH inhibition is removed, acts as an activator ensuring that 6-phosphogluconate is rapidly removed. NADP 6-phosphogluconate dehydrogenase, decarboxylating Ovis aries