Title : Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3.

Pub. Date : 1998 Dec

PMID : 9894610






2 Functional Relationships(s)
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1 Here we report that Bcl-2 and benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD-fmk), a broad spectrum caspase inhibitor, prevent loss of mitochondrial membrane potential (delta psi m) and the production of reactive oxygen species (ROS) caused by GC, while acetyl-Asp-Glu-Val-Asp-aldehyde (Ac-DEVD-CHO), an inhibitor of the caspase-3 family proteases, does not. acetyl-aspartyl-glutamyl-valyl-aspartal BCL2 apoptosis regulator Homo sapiens
2 Here we report that Bcl-2 and benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD-fmk), a broad spectrum caspase inhibitor, prevent loss of mitochondrial membrane potential (delta psi m) and the production of reactive oxygen species (ROS) caused by GC, while acetyl-Asp-Glu-Val-Asp-aldehyde (Ac-DEVD-CHO), an inhibitor of the caspase-3 family proteases, does not. acetyl-aspartyl-glutamyl-valyl-aspartal BCL2 apoptosis regulator Homo sapiens