Title : Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect.

Pub. Date : 1999 Jan 5

PMID : 9890890






1 Functional Relationships(s)
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1 Previous reaction schemes for substrate hydrolysis by AChE were extended to include product dissociation steps, and acetylthiocholine hydrolysis rates in the presence of propidium under nonequilibrium conditions were simulated with assigned rate constants in the program SCoP. Propidium acetylcholinesterase (Cartwright blood group) Homo sapiens