Title : Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver.

Pub. Date : 1999

PMID : 9890448






1 Functional Relationships(s)
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1 Results obtained by using chemical inhibitors or antibodies selectively active against specific CYPs provide a direct evidence for the involvement of CYP2C11, CYP3A2, and CYP2B1/2, indicating that each of them contributed about 40-50% of the diazinon metabolism, in hepatic microsomes from untreated, phenobarbital-, and dexamethasone-treated rats, respectively. Phenobarbital cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus