Title : Novel C5-dependent mechanism of neutrophil stimulation by bioincompatible dialyzer membranes.

Pub. Date : 1999 Jan

PMID : 9890318






2 Functional Relationships(s)
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1 In vitro incubation of isolated neutrophils in the presence of serum with hollow fibers of CU or polysulfone showed similar results: Only CU resulted in upregulation of CD11b and CD66b expression (by 65.5 +/- 18.7% and 60.1 +/- 24%) and a decrease in CD62L expression (by 60.6 +/- 18.2%). cuprammonium cellulose integrin subunit alpha M Homo sapiens
2 By using C5-depleted serum instead of normal human serum, up-/down-regulation of CD11b, CD62L, and CD66b by CU was dramatically reduced, whereas C3-depleted serum did not produce that effect. cuprammonium cellulose integrin subunit alpha M Homo sapiens