Title : The molecular basis of isolated 17,20 lyase deficiency.

Pub. Date : 1998 Aug-Nov

PMID : 9888582






2 Functional Relationships(s)
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1 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. Androstenedione cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. Androstenedione cytochrome P450 family 17 subfamily A member 1 Homo sapiens