Title : Synergistic activation of mitogen-activated protein kinase by cyclic AMP and myeloid growth factors opposes cyclic AMP's growth-inhibitory effects.

Pub. Date : 1999 Jan 15

PMID : 9885215






4 Functional Relationships(s)
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1 cAMP dramatically increased ERK activity in the presence of CSF-1 or IL-3. Cyclic AMP interleukin 3 Mus musculus
2 IL-3 also synergized with cAMP to activate ERK in another myeloid cell line, FDC-P1. Cyclic AMP interleukin 3 Mus musculus
3 cAMP treatment of 32D cells transfected with oncogenic Ras was found to recapitulate the superactivation of ERK seen with cAMP and CSF-1 or IL-3. Cyclic AMP interleukin 3 Mus musculus
4 These findings suggest that upregulation of the ERK pathway is one mechanism induced by CSF-1 and IL-3 to protect myeloid progenitors from the growth-suppressive and apoptosis-inducing effects of cAMP elevations. Cyclic AMP interleukin 3 Mus musculus