Pub. Date : 1999 Jan
PMID : 9884322
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, the mechanism for the decrease in ALDH1 activity after CY administration was investigated. | Cyclophosphamide | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 2 | The percentage of inhibition of ALDH1 activity in vivo by acrolein in patients receiving CY was calculated based on the in vitro Ki of acrolein, the in vitro Km of HCY, and the in vivo peak blood concentrations of HCY and acrolein. | Cyclophosphamide | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 3 | The calculations indicated that the activity of ALDH1 was inhibited by 85, 88, and 91% on days 1, 2, and 3 (24 h after the dose on day 2) of CY administration, respectively. | Cyclophosphamide | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |