Pub. Date : 1999 Jan 15
PMID : 9882625
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The activation of Erk-1/-2 by carbachol was blocked by the inhibition or down-regulation of protein kinase C (PKC). | Carbachol | protein kinase C epsilon | Homo sapiens |
| 2 | Among the multiple PKC isoforms expressed in SK-N-BE2(C) cells, only PKCepsilon was activated by the treatment of carbachol, and selective down-regulation of PKCepsilon was sufficient to block Erk-1/-2 activation. | Carbachol | protein kinase C epsilon | Homo sapiens |
| 3 | Among the multiple PKC isoforms expressed in SK-N-BE2(C) cells, only PKCepsilon was activated by the treatment of carbachol, and selective down-regulation of PKCepsilon was sufficient to block Erk-1/-2 activation. | Carbachol | protein kinase C epsilon | Homo sapiens |
| 4 | Thus, these results suggest that carbachol-induced activation of PKCepsilon mediates Erk-1/-2 activation by a sequential activation of Ras, Raf and MAP kinase kinase. | Carbachol | protein kinase C epsilon | Homo sapiens |