Title : Nonsubstrate recognition site residues are involved in testosterone hydroxylation by cytochrome P450 CYP 2C11.

Pub. Date : 1999 Jan 15

PMID : 9882461






2 Functional Relationships(s)
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1 Nonsubstrate recognition site residues are involved in testosterone hydroxylation by cytochrome P450 CYP 2C11. Testosterone cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 We have previously characterized an allelic variant of cytochrome P450 CYP 2C11 from the Gunn rat that differs at three positions (amino acids 4, 116, and 187) from the predominant allele from Wistar rats and that displays a dramatically reduced testosterone hydroxylation activity. Testosterone cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus