Pub. Date : 1998 Dec 3
PMID : 9879991
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines. | Cysteine | ret proto-oncogene | Homo sapiens |
| 2 | Germline mutations affecting one of five cysteines (Cys609, 611, 618, 620 and 634) located in the juxtamembrane domain of the RET receptor are responsible for the vast majority of two cancer-prone disorders, multiple endocrine neoplasia type 2A (MEN 2A) and familial medullary thyroid carcinoma (FMTC). | Cysteine | ret proto-oncogene | Homo sapiens |
| 3 | Germline mutations affecting one of five cysteines (Cys609, 611, 618, 620 and 634) located in the juxtamembrane domain of the RET receptor are responsible for the vast majority of two cancer-prone disorders, multiple endocrine neoplasia type 2A (MEN 2A) and familial medullary thyroid carcinoma (FMTC). | Cysteine | ret proto-oncogene | Homo sapiens |
| 4 | Germline mutations affecting one of five cysteines (Cys609, 611, 618, 620 and 634) located in the juxtamembrane domain of the RET receptor are responsible for the vast majority of two cancer-prone disorders, multiple endocrine neoplasia type 2A (MEN 2A) and familial medullary thyroid carcinoma (FMTC). | Cysteine | ret proto-oncogene | Homo sapiens |
| 5 | These findings provide a molecular basis explaining the range of phenotype engendered by alterations of RET cysteines and suggest a novel mechanism whereby mutations of cysteines 609, 618 and 620 exert both activating and inactivating effects. | Cysteine | ret proto-oncogene | Homo sapiens |
| 6 | These findings provide a molecular basis explaining the range of phenotype engendered by alterations of RET cysteines and suggest a novel mechanism whereby mutations of cysteines 609, 618 and 620 exert both activating and inactivating effects. | Cysteine | ret proto-oncogene | Homo sapiens |