Title : Enhancement of slow-wave sleep by tumor necrosis factor-alpha is mediated by cyclooxygenase-2 in rats.

Pub. Date : 1998 Dec 1

PMID : 9875706






1 Functional Relationships(s)
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1 The TNFalpha-induced SWS enhancement, fever and anorexia were all blocked by co-infusion of diclofenac, a non-selective cyclooxygenase (COX) inhibitor, and by pretreatment with NS-398, a COX-2-specific inhibitor. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide tumor necrosis factor Rattus norvegicus