Title : Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors.

Pub. Date : 1998 Dec 1

PMID : 9873746






1 Functional Relationships(s)
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1 Hybrid molecules built up by covalent coupling of aminopropanol derivatives (especially pindolol) with antidepressant drugs like fluoxetine, paroxetine or milnacipran were found to be potent and silent 5-HT1A antagonists (KB < 1 nM for 7c and 9a). Pindolol 5-hydroxytryptamine receptor 1A Homo sapiens