Title : Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.

Pub. Date : 1998 Jun 2

PMID : 9871776






2 Functional Relationships(s)
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1 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. catechol acetylcholinesterase (Cartwright blood group) Homo sapiens
2 From the modeling studies, the catechol analogue appeared capable of replacing one of the crystallographic waters bridging huperzine with Tyr 130 and Glu 199 of AChE. catechol acetylcholinesterase (Cartwright blood group) Homo sapiens