Title : Interpreting the effect of methyl group at the three carbon bridge of (-)-huperzine A on its anticholinesterase activity by molecular dynamics method.

Pub. Date : 1998 Mar 3

PMID : 9871590






1 Functional Relationships(s)
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1 It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively. Hydrogen acetylcholinesterase (Cartwright blood group) Homo sapiens