Title : Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction.

Pub. Date : 1998 Dec 15

PMID : 9865721






1 Functional Relationships(s)
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1 The iron chelator deferoxamine induced both HIF-1alpha and p53, but p53 up-regulation could still be detected in HIF-1alpha-deficient cells, suggesting that mechanisms other than HIF-1alpha activation contribute to oxygen-regulated p53 induction. Iron tumor protein p53 Homo sapiens