Pub. Date : 1998 Nov 27
PMID : 9862447
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytokine-induced activation of neutral SMase was inhibited by stimulation of protein kinase C (PKC) by the phorbol ester TPA which caused a reduction of ceramide back to control levels. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 2 | This inhibitory effect of TPA was reversed by the specific PKC-inhibitor Ro-318220. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 3 | Long-term incubation (24 h) of mesangial cells with TPA, which downregulates PKC-alpha, -delta, and -epsilon isoenzymes, resulted in a recovery of IL-1beta-stimulated neutral SMase activity as well as ceramide formation. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |