Title : Detoxification of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells.

Pub. Date : 1998 Nov

PMID : 9855012






2 Functional Relationships(s)
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1 To evaluate the influence of sterical crowding in the substrate on the activity of GSTP-1, the study was extended to the strongly mutagenic fjord-region (-)-anti-DEs of benzo[c]phenanthrene and dibenzo[a,l]pyrene. dibenzo(a,l)pyrene glutathione S-transferase P 1 Cricetulus griseus
2 Interestingly, the (-)-anti-DEs of benzo[c]phenanthrene and dibenzo[a,l]pyrene were efficiently detoxified by GSTP-1-1 in the constructed cell line (reduction of mutagenicity by 66 and 64%). dibenzo(a,l)pyrene glutathione S-transferase P 1 Cricetulus griseus