Title : Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation.

Pub. Date : 1998 Nov 10

PMID : 9843377






1 Functional Relationships(s)
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1 In transfected CHO cells expressing the human alpha2AAR, a 40.1 +/- 3.3% downregulation of Galphai2 protein occurred after 24 h of exposure of the cells to epinephrine, which was not accompanied by a decrease in Galphai2 mRNA. Epinephrine adrenoceptor alpha 2A Homo sapiens