Title : Stable expression of human alpha-2,6-sialyltransferase in Chinese hamster ovary cells: functional consequences for human erythropoietin expression and bioactivity.

Pub. Date : 1998 Nov 27

PMID : 9838208






1 Functional Relationships(s)
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1 Terminal sialylation of native human proteins is characteristically in both alpha-2,3 and alpha-2,6 linkage to galactose at the termini of N-linked oligosaccharides but only in alpha-2,3 linkage in recombinant proteins expressed in hamster cells which do not express alpha-2, 6-sialyltransferase (ST6GalI) (EC 2.4.99.1). Galactose ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Homo sapiens