Pub. Date : 1998
PMID : 9833158
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Angiotensin II is able to modulate both the presynaptic sympathetic system and the adrenal medulla resulting in an enhanced release of noradrenaline and adrenaline. | Norepinephrine | angiotensinogen | Rattus norvegicus |
| 2 | Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release. | Norepinephrine | angiotensinogen | Rattus norvegicus |
| 3 | As could be demonstrated with losartan and HR 720, candesartan lowered AT1 receptor mediated angiotensin II-induced noradrenaline release in a dose-dependent manner. | Norepinephrine | angiotensinogen | Rattus norvegicus |