Title : In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.

Pub. Date : 1998 Oct

PMID : 9825830






2 Functional Relationships(s)
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Protein Name
Organism
1 Ketoconazole and troleandomycin, inhibitors of CYP3A4, inhibited competitively both haloperidol and CPHP formation, with a Ki value lower than 0.2 microM for ketoconazole and lower than 0.3 microM for troleandomycin. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Ketoconazole and troleandomycin, inhibitors of CYP3A4, inhibited competitively both haloperidol and CPHP formation, with a Ki value lower than 0.2 microM for ketoconazole and lower than 0.3 microM for troleandomycin. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens