Title : Novel inhibitors of cyclooxygenase-2: the sulfones and sulfonamides of 1,2-diaryl-4,5-difluorobenzene. Analysis of quantitative structure-activity relationship.

Pub. Date : 1998 Sep

PMID : 9825305






1 Functional Relationships(s)
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1 By a quantitative structure-activity relationship (QSAR) study, the inhibitory activity of a novel series of sulfones and sulfonamides of 1,2-diaryl-4,5-difluorobenzene, against the inducible form of cyclooxygenase (COX-2) was shown to be significantly correlated with the electronic constant (sigma) and some suitable indicator parameters. Sulfonamides mitochondrially encoded cytochrome c oxidase II Homo sapiens