Pub. Date : 1998 Oct 9
PMID : 9822896
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. | Erythromycin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The basal-to-apical transport of rhodamine 123, a P-glycoprotein substrate, was inhibited by erythromycin, midazolam and ketoconazole, as well as by P-glycoprotein inhibitors such as verapamil. | Erythromycin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In conclusion, erythromycin, midazolam and ketoconazole could interact with P-glycoprotein-mediated transport, and P-glycoprotein could be, at least in part, involved in the transport of erythromycin, but not of midazolam and ketoconazole, in the intestinal epithelia. | Erythromycin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | In conclusion, erythromycin, midazolam and ketoconazole could interact with P-glycoprotein-mediated transport, and P-glycoprotein could be, at least in part, involved in the transport of erythromycin, but not of midazolam and ketoconazole, in the intestinal epithelia. | Erythromycin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | In conclusion, erythromycin, midazolam and ketoconazole could interact with P-glycoprotein-mediated transport, and P-glycoprotein could be, at least in part, involved in the transport of erythromycin, but not of midazolam and ketoconazole, in the intestinal epithelia. | Erythromycin | ATP binding cassette subfamily B member 1 | Homo sapiens |