Title : Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA.

Pub. Date : 1998 Nov 27

PMID : 9822711






1 Functional Relationships(s)
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1 This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486. Mifepristone mitochondrially encoded cytochrome c oxidase II Homo sapiens