Pub. Date : 1998 Nov 27
PMID : 9822711
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Up-regulation of COX-2 is responsible for increased PG production in inflammation and is antagonized by corticosteriods such as dexamethasone. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Nuclear run-off assays showed that COX-2 transcription rate was repressed 25-40% by dexamethasone, while PGE2 release, COX activity, and COX-2 protein were totally repressed. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Preinduced COX-2 mRNA was also potently repressed by dexamethasone, yet suppression of transcription by actinomycin D showed little effect. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 6 | Following dexamethasone treatment, shortening of the average length of COX-2 mRNA poly(A) tails was observed. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 7 | In conclusion, these data indicate a major role for post-transcriptional mechanisms in the dexamethasone-dependent repression of COX-2 that require de novo glucocorticoid receptor-dependent transcription and translation. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |