Title : Peroxynitrite mediates IL-8 gene expression and production in lipopolysaccharide-stimulated human whole blood.

Pub. Date : 1998 Nov 15

PMID : 9820546






3 Functional Relationships(s)
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1 Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood. Superoxides C-X-C motif chemokine ligand 8 Homo sapiens
2 Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood. Superoxides C-X-C motif chemokine ligand 8 Homo sapiens
3 Combination of the NO-generating chemicals with a superoxide-generating system (xanthine/xanthine oxidase) markedly increased IL-8 release. Superoxides C-X-C motif chemokine ligand 8 Homo sapiens