Title : Induction of apoptosis and cell cycle-specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard.

Pub. Date : 1995 Aug

PMID : 9816057






4 Functional Relationships(s)
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1 Induction of apoptosis and cell cycle-specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard. Nitrogen tumor protein p53 Homo sapiens
2 Exposure of normal lymphocytes to 5 microM nitrogen mustard caused their arrest in G1, an increase in p53 expression which was maximal in such cells, and significant apoptosis in cells located beyond the arrest point (S and G2 + M cells). Nitrogen tumor protein p53 Homo sapiens
3 Expression of p53 was highest for S and G2 + M MOLT-4 cells in response to the nitrogen mustard. Nitrogen tumor protein p53 Homo sapiens
4 These data suggest that DNA damage caused by nitrogen mustard provides a signal that results in stabilization of wild-type p53, preferentially in G1 cells, causes cell arrest in G1, and induces apoptosis of the cells that either were in the S-phase at the time of drug administration and/or escaped G1 arrest. Nitrogen tumor protein p53 Homo sapiens