Title : p53 mutation and tamoxifen resistance in breast cancer.

Pub. Date : 1995 Oct

PMID : 9815913






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 To test the hypothesis that a p53 mutation could result in tamoxifen resistance and estrogen-independent growth, the MCF-7 cell line was transfected with p53 cDNA which was mutated at codon 179 (histidine to glutamine). Tamoxifen tumor protein p53 Homo sapiens
2 MCF-7 is an estrogen receptor-positive, estrogen-dependent, tamoxifen-sensitive cell line with only wild-type p53. Tamoxifen tumor protein p53 Homo sapiens