Title : Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function.

Pub. Date : 1997 Aug

PMID : 9815821






3 Functional Relationships(s)
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1 This p53-defective cell line was also radiosensitized by CAF, whereas the vector control (AA/PCMV/D), which retained wt p53 activity, was not. Caffeine tumor protein p53 Homo sapiens
2 This suggests that radiosensitization by CAF and increased cell death is dependent on loss of wt p53 function. Caffeine tumor protein p53 Homo sapiens
3 These results demonstrate that G2 checkpoint inhibition with CAF leads to preferential IR cell killing in cell lines in which wt p53 is inactivated and that this increased cell killing is not necessarily dependent on increased IR-induced apoptosis. Caffeine tumor protein p53 Homo sapiens