Title : A phase I study of topotecan followed sequentially by doxorubicin in patients with advanced malignancies.

Pub. Date : 1997 May

PMID : 9815746






1 Functional Relationships(s)
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1 In 7 of 10 patients, there was an increase (16.6 +/- 2.9% to 25.0 +/- 3.5%; P < 0.02) in the proportion of CD34+ cells in S-phase 24 h after the topotecan infusion and prior to doxorubicin compared to the pretreatment values, whereas 1 patient had a decrease in the proportion of CD34+ cells in S phase and 2 patients had no change. Topotecan CD34 molecule Homo sapiens