Title : UCN-01 in ovary cancer cells: effective as a single agent and in combination with cis-diamminedichloroplatinum(II)independent of p53 status.

Pub. Date : 1997 Nov

PMID : 9815601






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The degree of sensitization to CDDP conferred by UCN-01, however, was found to correlate with p53 gene status. Cisplatin tumor protein p53 Homo sapiens
2 p53 wild-type cells seem to be more sensitive to the cytotoxic effects of the combination of UCN-01 + CDDP than the p53 mutant cells. Cisplatin tumor protein p53 Homo sapiens
3 This was confirmed in cells in which p53 wild-type function was restored by transfection of p53 cDNA, but these cells are also significantly more sensitive to CDDP alone. Cisplatin tumor protein p53 Homo sapiens