Title : Insulin inhibits delta-aminolevulinate synthase gene expression in rat hepatocytes and human hepatoma cells.

Pub. Date : 1998 Nov 1

PMID : 9806796






2 Functional Relationships(s)
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1 The addition of 5 nM insulin to hepatocytes culture led to a significant decrease of both basal and phenobarbital-induced ALA-S mRNA in a dose-dependent manner, as measured by Northern and slot-blot analysis. Phenobarbital insulin Homo sapiens
2 Our results demonstrate that the insulin effect is dominant; it overrides 8-CPT-cAMP plus phenobarbital-mediated induction. Phenobarbital insulin Homo sapiens