Title : Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.

Pub. Date : 1998 Nov

PMID : 9804609






1 Functional Relationships(s)
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1 These results indicate that mersalyl induces expression of HIF-1 and a subset of hypoxia-inducible genes by a mechanism, involving the insulin-like growth factor-1 receptor and mitogen-activated protein kinase activity, that is distinct from mechanisms of induction by hypoxia, CoCl2, or DFO. Mersalyl insulin like growth factor 1 receptor Homo sapiens