Title : Hypochlorous acid activates the tumor suppressor protein p53 in cultured human skin fibroblasts.

Pub. Date : 1998 Nov 1

PMID : 9799559






2 Functional Relationships(s)
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Protein Name
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1 The increase in p53 required the myeloperoxidase-dependent generation of hypochlorous acid and could be mimicked by exposing cells to a flux of hypochlorous acid produced by purified myeloperoxidase and a hydrogen peroxide-generating system. Hydrogen Peroxide tumor protein p53 Homo sapiens
2 Hydrogen peroxide alone also elevated p53 and WAF1/CIP1, but the fluxes required were nearly 10-fold higher than those that were effective for hypochlorous acid. Hydrogen Peroxide tumor protein p53 Homo sapiens