Title : Hypochlorous acid activates the tumor suppressor protein p53 in cultured human skin fibroblasts.

Pub. Date : 1998 Nov 1

PMID : 9799559






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Neutrophils accumulate at sites of chronic inflammation, where they are stimulated to produce hydrogen peroxide which is converted to hypochlorous acid by coreleased myeloperoxidase. Hypochlorous Acid myeloperoxidase Homo sapiens
2 The increase in p53 required the myeloperoxidase-dependent generation of hypochlorous acid and could be mimicked by exposing cells to a flux of hypochlorous acid produced by purified myeloperoxidase and a hydrogen peroxide-generating system. Hypochlorous Acid myeloperoxidase Homo sapiens
3 The increase in p53 required the myeloperoxidase-dependent generation of hypochlorous acid and could be mimicked by exposing cells to a flux of hypochlorous acid produced by purified myeloperoxidase and a hydrogen peroxide-generating system. Hypochlorous Acid myeloperoxidase Homo sapiens
4 The increase in p53 required the myeloperoxidase-dependent generation of hypochlorous acid and could be mimicked by exposing cells to a flux of hypochlorous acid produced by purified myeloperoxidase and a hydrogen peroxide-generating system. Hypochlorous Acid myeloperoxidase Homo sapiens