Title : Elevation of cyclic AMP decreases phosphoinositide turnover and inhibits thrombin-induced secretion in human platelets.

Pub. Date : 1998 Nov 2

PMID : 9795233






1 Functional Relationships(s)
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1 The thrombin-induced (0.1 U/ml) increase in production of [32P]PA, "overshoots" in [32P]PIP and [32P]PIP2 ([32P]phosphatidylinositol 4,5-bisphosphate), and the increase in [32P]PI and secretion of ADP+ATP were abolished by forskolin (10-7 M). Protactinium coagulation factor II, thrombin Homo sapiens