Pub. Date : 1998 Sep
PMID : 9794256
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Beta-adrenergic receptors transduce catecholamine binding to activation of adenylylcyclase, a response counter-regulated by insulin. | Catecholamines | insulin | Cricetulus griseus |
| 2 | Insulin stimulates tyrosine phosphorylation of Tyr 350/354, which abolishes the catecholamine response. | Catecholamines | insulin | Cricetulus griseus |
| 3 | These data provide a biochemical link between the ability of insulin to counter-regulate catecholamine stimulation of cyclic AMP accumulation and the phosphorylation of the beta-adrenergic receptor, consequent biding of the adaptor molecule Grb2 and disruption of receptor-G-protein coupling. | Catecholamines | insulin | Cricetulus griseus |