Title : Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells.

Pub. Date : 1998 Sep 15

PMID : 9788582






3 Functional Relationships(s)
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1 The direct-acting NTE inhibitors block process outgrowth by 50% or more at 50-100 microM for OBDPO and 100-200 microM for mipafox, well below their cytotoxic levels (EC50 values, 445-474 microM for OBDPO and 1021-1613 microM for mipafox). mipafox patatin-like phospholipase domain containing 6 Rattus norvegicus
2 The direct-acting NTE inhibitors block process outgrowth by 50% or more at 50-100 microM for OBDPO and 100-200 microM for mipafox, well below their cytotoxic levels (EC50 values, 445-474 microM for OBDPO and 1021-1613 microM for mipafox). mipafox patatin-like phospholipase domain containing 6 Rattus norvegicus
3 These findings suggest that inhibition of neurite-like and cell process outgrowth by OBDPO and mipafox may be associated with NTE inhibition. mipafox patatin-like phospholipase domain containing 6 Rattus norvegicus