Pub. Date : 1998 Oct 30
PMID : 9786868
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells. | Nicotine | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |
| 2 | Nicotine was a partial agonist on alpha3 beta4 AChRs and nearly a full agonist on alpha3 beta2 alpha5 AChRs. | Nicotine | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |
| 3 | Chronic exposure of cells expressing alpha3 beta2 AChRs or alpha3 beta2 alpha5 AChRs to nicotine or carbamylcholine increased their amount up to 24-fold but had no effect on the amount of alpha3beta4 or alpha3 beta4 alpha5 AChRs, i.e. the up-regulation of alpha3 AChRs depended on the presence of beta2 but not beta4 subunits in the AChRs. | Nicotine | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |
| 4 | Chronic exposure of cells expressing alpha3 beta2 AChRs or alpha3 beta2 alpha5 AChRs to nicotine or carbamylcholine increased their amount up to 24-fold but had no effect on the amount of alpha3beta4 or alpha3 beta4 alpha5 AChRs, i.e. the up-regulation of alpha3 AChRs depended on the presence of beta2 but not beta4 subunits in the AChRs. | Nicotine | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |
| 5 | Chronic exposure of cells expressing alpha3 beta2 AChRs or alpha3 beta2 alpha5 AChRs to nicotine or carbamylcholine increased their amount up to 24-fold but had no effect on the amount of alpha3beta4 or alpha3 beta4 alpha5 AChRs, i.e. the up-regulation of alpha3 AChRs depended on the presence of beta2 but not beta4 subunits in the AChRs. | Nicotine | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |
| 6 | In the absence of nicotine, alpha3 beta2 AChRs were expressed at much lower levels than alpha3 beta4 AChRs, but in the presence of nicotine, the amount of alpha3 beta2 AChRs exceeded that of alpha3 beta4 AChRs. | Nicotine | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |
| 7 | Our data suggest that up-regulation of alpha3 beta2 AChRs in these lines by nicotine results from both increased subunit assembly and decreased AChR turnover. | Nicotine | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |