Title : Ca2+-dependent production and release of IL-8 in human neutrophils.

Pub. Date : 1998 Oct 15

PMID : 9780210






1 Functional Relationships(s)
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1 Incubation of peripheral blood neutrophils with thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+-sequestering-ATPase, causes a dose-dependent induction of IL-8 synthesis that continues for up to 8 h. Cycloheximide inhibits the thapsigargin-induced IL-8 production, suggesting the induction of protein synthesis de novo. Cycloheximide C-X-C motif chemokine ligand 8 Homo sapiens